Improved Specificity of 18F-FDG PET/CT for Lymph Node Staging of Non-Small Cell Lung Cancer Considering Calcified Lymph Node as Benign.
- Author:
Seong Young KWON
1
;
Young Soon SEO
;
Jung Joon MIN
;
Ho Chun SONG
;
Kook Joo NA
;
Chan CHOI
;
Young Chul KIM
;
Yun Hyun KIM
;
Hee Seung BOM
Author Information
1. Department of Nuclear Medicine, Chonnam National University Hospital, Gwangju, Korea. hsbom@jnu.ac.kr
- Publication Type:Original Article
- Keywords:
non-small cell lung cancer;
lymph node staging;
calcification;
histology;
18F-FDG PET/CT
- MeSH:
Adenocarcinoma;
Biopsy;
Carcinoma, Non-Small-Cell Lung*;
Carcinoma, Squamous Cell;
Diagnosis;
Female;
Fluorodeoxyglucose F18*;
Humans;
Lymph Nodes*;
Male;
Neoplasm Metastasis;
Positron-Emission Tomography and Computed Tomography*;
Sensitivity and Specificity*
- From:Nuclear Medicine and Molecular Imaging
2007;41(1):16-21
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We evaluated the diagnostic value of 18F-FDG PET/CT (PET/CT) in lymph node staging of non-small cell lung cancer (NSCLC) considering calcification and histologic types as well as FDG uptake. MATERIALS AND METHODS: Fifty-three patients (38 men, 15 women; mean age, 62 years) with NSCLC underwent surgical resection (tumor resection and lymph node dissection) after PET/CT. After surgery, we compared PET/CT results with the biopsy results, and analyzed lymph node metastases, based on histologic types. PET diagnosis of lymph node metastasis was determined by maximum SUV (maxSUV) > 3.0, and PET/CT diagnosis was determined by maxSUV > 3.0 without lymph node calcification. RESULTS: By PET diagnosis, the sensitivity, specificity, and accuracy of overall lymph node staging were 45% (13 of 29), 91% (228 of 252), and 86% (241 of 281). Specificity was 91% in both squamous cell carcinoma and adenocarcinoma, while sensitivity was 71% in squamous cell carcinoma and 36% in adenocarcinoma. When we excluded calcified lymph node with maxSUV > 3.0 from metastasis by PET/CT diagnosis, specificity improved to 98% in squamous cell carcinoma and 97% in adenocarcinoma. The degree of improvement was not dependent on histologic types. CONCLUSION: PET/CT improved specificity of lymph node staging by reducing false positive lymph node regardless of histologic types of NSCLC.
