Extracellular Matrix Revisited: Roles in Tissue Engineering.
- Author:
Youhwan KIM
1
;
Hyojin KO
;
Ik Keun KWON
;
Kwanwoo SHIN
Author Information
1. Department of Chemistry and Institute of Biological Interfaces, Sogang University, Seoul, Korea. kwshin@sogang.ac.kr
- Publication Type:Review
- Keywords:
Extracellular Matrix;
Tissue Engineering;
Fibronectin;
Collagen;
Elastin;
Cell Sheets
- MeSH:
Biomedical Engineering;
Biophysics;
Cellular Structures;
Collagen;
Cues;
Elastin;
Extracellular Matrix*;
Fibronectins;
Glycoproteins;
Homeostasis;
Morphogenesis;
Tissue Engineering*
- From:International Neurourology Journal
2016;20(Suppl 1):S23-S29
- CountryRepublic of Korea
- Language:English
-
Abstract:
The extracellular matrix (ECM) is a heterogeneous, connective network composed of fibrous glycoproteins that coordinate in vivo to provide the physical scaffolding, mechanical stability, and biochemical cues necessary for tissue morphogenesis and homeostasis. This review highlights some of the recently raised aspects of the roles of the ECM as related to the fields of biophysics and biomedical engineering. Fundamental aspects of focus include the role of the ECM as a basic cellular structure, for novel spontaneous network formation, as an ideal scaffold in tissue engineering, and its essential contribution to cell sheet technology. As these technologies move from the laboratory to clinical practice, they are bound to shape the vast field of tissue engineering for medical transplantations.
