Influence of Droperidol on Postoperative Nausea and Vomiting during Patient-Controlled Analgesia with Fentanyl.
10.4097/kjae.1998.34.1.132
- Author:
Sang Min PARK
1
;
Soon Im KIM
;
Wook PARK
Author Information
1. Department of Anesthesiology, Soonchunhyang University Hospital, Seoul, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Analgesics: intravenous;
fentanyl;
Pharmacology: droperidol;
Vomiting: nausea;
postoperative
- MeSH:
Analgesia;
Analgesia, Patient-Controlled*;
Antiemetics;
Droperidol*;
Female;
Fentanyl*;
Humans;
Incidence;
Male;
Orthopedics;
Passive Cutaneous Anaphylaxis;
Postoperative Nausea and Vomiting*
- From:Korean Journal of Anesthesiology
1998;34(1):132-136
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
INTRODUCTION: Patient-controlled analgesia (PCA) has become an important means for postoperative analgesia with parenteral opioid, but postoperative nausea and vomiting (PONV) remains a major problem using a PCA system. The present study was designed to assess the antiemetic effectiveness of droperidol in patients using an intravenous PCA during the first 24 hours after surgery. METHODS: For the postoperative analgesia, 80 patients underwent orthopedic surgery were randomly allocated to receive PCA with either a mixture of 3.75 mg droperidol and fentanyl 2500 microgram after initial bolus of 1.25 mg droperidol as the FD group, or a mixture of saline and fentanyl 2500 microgram as the FS group at the end of surgery. RESULTS: The incidence of PONV showed 52.5% in FS group and 15% in FD group respectively (P<0.05). The incidence of PONV was 2~3 times more in women (76% in FS group & 25% in FD group) than men (35% in FS group & 9% in FD group). CONCLUSION: The addition of droperidol to fentanyl in a PCA system reduces the PONV during the first 24 hours after surgery.
