Report of 3 Cases of Chronic Myelogenous Leukemia with Thrombocythemic Onset.
- Author:
Hee Won MOON
1
;
Jin Hee PARK
;
Jung Sook YOON
;
Jeong Yeal AHN
;
Jung Won HUH
;
Ki Sook HONG
;
Wha Soon CHUNG
Author Information
1. Department of Clinical Pathology, Ewha Womans University, College of Medicine, Seoul, Korea. wschung@mm.ewha.ac.kr
- Publication Type:Original Article
- Keywords:
Chronic myelogenous leukemia;
Thrombocythemic onset;
Basophilia;
Essential throm-bocythemia
- MeSH:
Bone Marrow;
Diagnosis;
Diagnosis, Differential;
Eosinophilia;
Fibrosis;
Gene Rearrangement;
Granulocytes;
Humans;
Hydrogen-Ion Concentration;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*;
Leukocytosis;
Myeloid Cells;
Thrombocythemia, Essential;
Thrombocytosis
- From:The Korean Journal of Laboratory Medicine
2002;22(3):159-162
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Differential diagnosis may be difficult between essential thrombocythemia (ET) and chronic myelogenous leukemia (CML) with marked thrombocytosis, mild leukocytosis, and a few immature myeloid cells in peripheral blood at onset. The aim of the present study was to analyze clinical, hematologic, and molecular features of patients with CML, mimicking ET. METHODS: Among patients from Ewha and Gachon Gil Medical Center between January 1990 and June 2001, our study group included 3 patients with Ph-positive CML with marked thrombocy-tosis (>600 X 10(9)/L) and mild leukocytosis (<20 X 10(9)/L) and 12 patients of the typical ET as a con-trol group. RESULTS: Peripheral blood basophilia (4 - 12%) and a few immature granulocytes (1 - 9%) were the characteristic features of CML with thrombocythemic onset, compared with the typical ET. There was no evidence of bone marrow eosinophilia, basophilia, or fibrosis in CML with thrombocythemic onset. CONCLUSIONS: Our study suggests that peripheral basophilia as well as the positivity of Ph chromo-somes or bcr/abl gene rearrangement can be a clue to diagnosis of CML.
