Does Diabetes Mellitus Influence Standardized Uptake Values of Fluorodeoxyglucose Positron Emission Tomography in Colorectal Cancer?.
- Author:
Da Yeon OH
1
;
Ji Won KIM
;
Seong Joon KOH
;
Mingoo KIM
;
Ji Hoon PARK
;
Su Yeon CHO
;
Byeong Gwan KIM
;
Kook Lae LEE
;
Jong Pil IM
Author Information
- Publication Type:Original Article
- Keywords: Diabetes mellitus; Positron emission tomography; Colorectal neoplasms
- MeSH: Colorectal Neoplasms*; Diabetes Mellitus*; Glucose; Hemoglobin A, Glycosylated; Humans; Hyperglycemia; Linear Models; Medical Records; Positron-Emission Tomography*; Retrospective Studies
- From:Intestinal Research 2014;12(2):146-152
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Hyperglycemia is associated with decreased 2-18[F]fluoro-2-deoxy-D-glucose (FDG) uptake by tumors assessed by positron emission tomography (PET). In this retrospective study we investigated a comparison of standardized uptake values (SUVs) in patients with primary colorectal cancers who either had diabetes mellitus (DM) or were otherwise healthy. METHODS: The medical records of 397 patients who were diagnosed with colorectal cancer and underwent PET-CT between January 2006 and December 2012 were analyzed. Eighty patients with DM and 317 patients without DM were included. Clinical characteristics were reviewed and maximal standardized uptake values (SUVmax) were calculated in the primary colorectal lesions. RESULTS: There was no significant difference between tumor SUVmax in DM patients (10.60+/-5.78) and those without DM (10.92+/-5.44). In addition, no significant difference was detected between tumor SUVmax in DM patients with glycated hemoglobin (HbA1c) levels <8% (10.34+/-5.17) and those with HbA1c levels > or =8% (10.61+/-7.27). The maximum size of the primary colorectal tumor was associated with SUVmax in a linear regression analysis. CONCLUSION: The results of this study showed that DM did not influence FDG uptake values in colorectal cancer patients regardless of glucose levels.
