Aberrant DNA Double-strand Break Repair Threads in Breast Carcinoma: Orchestrating Genomic Insult Survival.
10.15430/JCP.2016.21.4.227
- Author:
Azad KUMAR
1
;
Shruti PUROHIT
;
Nilesh Kumar SHARMA
Author Information
1. Cancer and Translational Research Lab, Dr. D. Y. Patil Biotechnology & Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. nilesh.sharma@dpu.edu.in
- Publication Type:Review
- Keywords:
Genotoxic drug;
DNA repair;
Breast carcinoma;
Drug therapy;
Radiotherapy
- MeSH:
Breast Neoplasms*;
Breast*;
DNA Repair;
DNA*;
Drug Therapy;
Genotype;
Homologous Recombination;
Phenotype;
Radiotherapy
- From:Journal of Cancer Prevention
2016;21(4):227-234
- CountryRepublic of Korea
- Language:English
-
Abstract:
Breast carcinoma is a heterogeneous disease that has exhibited rapid resistance to treatment in the last decade. Depending genotype and phenotype of breast cancer, there are discernible differences in DNA repair protein responses including DNA double strand break repair. It is a fact that different molecular sub-types of breast carcinoma activate these dedicated protein pathways in a distinct manner. The DNA double-strand damage repair machinery is manipulated by breast carcinoma to selectively repair the damage or insults inflicted by the genotoxic effects of chemotherapy or radiation therapy. The two DNA double-strand break repair pathways employed by breast carcinoma are homologous recombination and non-homologous end joining. In recent decades, therapeutic interventions targeting one or more factors involved in repairing DNA double-strand breaks inflicted by chemo/radiation therapy have been widely studied. Herein, this review paper summarizes the recent evidence and ongoing clinical trials citing potential therapeutic combinatorial interventions targeting DNA double-strand break repair pathways in breast carcinoma.
