Antimicrobial Susceptibility Patterns of Legionella isolates in the Environment and in Patients.
10.3343/kjlm.2010.30.1.28
- Author:
Go Eun CHOI
1
;
Jeong Eun KANG
;
Eun Yup LEE
;
Chulhun L CHANG
;
Kazuhiro TATEDA
;
Keizo YAMAGUCHI
;
Kyeong Hee KIM
;
Jeong Man KIM
Author Information
1. Department of Laboratory Medicine, Pusan National University School of Medicine, Busan, Korea.
- Publication Type:Original Article ; English Abstract
- Keywords:
Legionella;
Antimicrobial susceptibility;
Buffered starch yeast extract broth
- MeSH:
Anti-Bacterial Agents/*pharmacology;
Azithromycin/pharmacology;
Ciprofloxacin/pharmacology;
Clarithromycin/pharmacology;
Clindamycin/pharmacology;
Drug Resistance, Bacterial;
Fluoroquinolones/pharmacology;
Humans;
Legionella/*drug effects/isolation & purification;
Legionellosis/diagnosis/microbiology;
Microbial Sensitivity Tests;
Naphthyridines/pharmacology
- From:The Korean Journal of Laboratory Medicine
2010;30(1):28-33
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Antimicrobial susceptibility of Legionella spp. has rarely been studied in Korea. Therefore, we aimed to determine the susceptibility of Legionella spp. to various antibiotics. METHODS: We assessed the antimicrobial susceptibility of 66 environmental and clinical Legionella isolates collected between January 2001 and December 2008 from Korea and Japan. The minimum inhibitory concentrations (MICs) of 6 antibiotics, namely, azithromycin, ciprofloxacin, clarithromycin, clindamycin, gatifloxacin, and gemifloxacin were determined by the broth microdilution method using buffered starch yeast extract broth. RESULTS: The MIC ranges of the 6 antibiotics used against the Legionella isolates were as follows: 0.004-0.062 microgram/mL (azithromycin), 0.002-0.5 microgram/mL (ciprofloxacin), 0.004-0.5 microgram/mL (clarithromycin), 0.12-4 microgram/mL (clindamycin), 0.002-0.12 microgram/mL (gatifloxacin), and 0.008-1 microgram/mL (gemifloxacin). CONCLUSIONS: Legionella spp. isolates from Korea and Japan were most susceptible to gatifloxacin. Azithromycin, clarithromycin, ciprofloxacin, and gemifloxacin were also effective for treating legionellosis.
