The Change of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in the Gastric Mucosa One Year after Eradication of Helicobacter pylori.
- Author:
Sung Soo KIM
1
;
Young Jick SUNG
;
Min Kyoung PARK
;
Chang Hoon LIM
;
Hong Jun YANG
;
Tae Ho KIM
;
Chang Whan KIM
;
Jin Il KIM
;
Sok Won HAN
;
In Sik CHUNG
Author Information
1. Division of Gastroenterology, Department Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. swhan54@yahoo.co.kr
- Publication Type:Original Article ; English Abstract
- Keywords:
Helicobacter pylori, eradication;
Cyclooxygenase-2;
Inducible nitric oxide synthase
- MeSH:
Cyclooxygenase 2/immunology/*metabolism;
Drug Therapy, Combination;
Gastric Mucosa/*enzymology;
Helicobacter Infections/drug therapy;
*Helicobacter pylori;
Humans;
Nitric Oxide Synthase Type II/immunology/*metabolism;
Time Factors
- From:The Korean Journal of Gastroenterology
2008;52(5):286-292
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: The cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), the proteins that have the role in the gastric carcinogenesis, are stimulated by H. pylori infection in the gastric mucosa. The aim of this study was to evaluate the expression of COX-2 and iNOS proteins one year after the eradication of H. pylori. METHODS: Gastric antral mucosa from fifty eight patients with chronic gastritis who were all infected with H. pylori was examined for the expression of COX-2 and iNOS proteins before and one year after the eradication of H. pylori by immunohistochemical stain. RESULTS: COX-2 and iNOS proteins were expressed in the epithelial cells and interstitial inflammatory cells of gastric mucosa. Percent expressions of COX-2 and iNOS were significantly decreased one year after the eradication in the patients with cured infection, but not in those having persistent H. pylori. COX-2 and iNOS expressions were well correlated with H. pylori density, acute and chronic inflammation of gastric mucosa. CONCLUSIONS: The eradication of H. pylori can decrease the expression of COX-2 and iNOS in the gastric mucosa in long-term period. This seems to be due to the removal of H. pylori itself and related regression of gastric inflammation.
