A Case of Woringer-Kolopp Disease of the Hand.
- Author:
Ha Ryeong RYU
1
;
Jeong Soo KIM
;
Chul Hyun YUN
;
Ji Hoon KIM
;
Joo Young ROH
;
Jong Rok LEE
;
Hyun Chul KIM
;
Jin Ok BAEK
Author Information
1. Department of Dermatology, Gachon University, Gil Medical Center, Incheon, Korea. jobaek79@gmail.com
- Publication Type:Case Report
- Keywords:
Woringer-Kolopp disease;
Pagetoid reticulosis
- MeSH:
Adult;
Biopsy;
Dermis;
Epidermis;
Extremities;
Hand*;
Humans;
Lymphocytes;
Mechlorethamine;
Mycosis Fungoides;
Pagetoid Reticulosis*;
Phototherapy;
Physical Examination;
Skin;
Steroids;
T-Lymphocytes
- From:Korean Journal of Dermatology
2016;54(7):552-556
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Woringer-Kolopp disease, also known as localized pagetoid reticulosis, is a rare variant of mycosis fungoides that presents as a solitary localized hyperkeratotic patch or plaque on the extremities and follows a benign course. Effective treatments for Woringer-Kolopp disease include skin-directed therapies such as topical nitrogen mustard, high-potency topical steroids, and phototherapy. Surgical excision has been pursued in cases of small, localized lesions. A 39-year-old man presented with a 3-month history of an asymptomatic plaque on his hand. Physical examination showed a 10-mm-diameter solitary round erythematous hyperkeratotic plaque with a slightly raised edge on the dorsum of his left hand. A skin biopsy revealed that numerous atypical lymphocytes had infiltrated the upper dermis and expanded into the epidermis with a pagetoid pattern. These atypical pagetoid cells were strongly positive for CD3, CD8, and T-cell intracellular antigen-1; focally positive for CD4; and negative for CD20, CD30, and CD56. A subsequent general examination revealed no evidence of systemic involvement and the lesion was treated with surgical excision. Here we report a rare case of Woringer-Kolopp disease.
