Vitamin D Status and Its Relationship with Disease Severity/activity in Patients with Atopic Dermatitis, Psoriasis, and Chronic Idiopathic Urticaria in Korea.
- Author:
Wonjeong KIM
1
;
Jun Young KIM
;
Min Young PARK
;
Margaret SONG
;
Hoon Soo KIM
;
Hyun Chang KO
;
Byung Soo KIM
;
Moon Bum KIM
Author Information
1. Department of Dermatology, School of Medicine, Pusan National University, Busan, Korea. backing04@hanmail.net
- Publication Type:Original Article
- Keywords:
Atopic dermatitis;
Chronic urticaria;
Deficiency;
Psoriasis;
Vitamin D
- MeSH:
Cross-Sectional Studies;
Dermatitis, Atopic*;
Humans;
Korea;
Psoriasis*;
Skin Diseases;
Skin Neoplasms;
Urticaria*;
Vitamin D*
- From:Korean Journal of Dermatology
2015;53(3):209-216
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Deficiency of vitamin D is reported to be an important factor associated with various dermatoses such as atopic dermatitis, psoriasis, urticaria, and skin cancers. However, this association is disputable and has not been clarified. OBJECTIVE: To evaluate the status of serum 25-hydroxyvitamin D in patients with atopic dermatitis, psoriasis, and chronic urticaria, and examine the relationship between vitamin D levels and disease severity/activity compared with sex- and age-matched healthy controls. METHODS: A cross-sectional study of 23, 34, and 73 patients with atopic dermatitis, psoriasis, and chronic idiopathic urticaria, respectively, and sex- and age-matched controls was conducted. Objective severity scoring of atopic dermatitis (eczema area and severity index) and psoriasis (psoriasis area and severity index), the urticaria activity score, and serum 25-hydroxyvitamin D levels were measured for each subject. RESULTS: Serum 25-hydroxyvitamin D levels were significantly lower in atopic dermatitis patients than those in the controls (p<0.05). However, mean vitamin D levels in psoriasis and chronic idiopathic urticaria patients were not significantly lower than those in the controls (p>0.05). Furthermore, no significant inverse correlation was found between disease severity and serum 25-hydroxyvitamin D levels in atopic dermatitis, psoriasis, and chronic idiopathic urticaria patients (p>0.05). CONCLUSION: The impact of vitamin D in these dermatoses seems to be overestimated and needs further study to prove any true association.
