Risk Potentiality of Frontline Radiotherapy Associated Cataract in Primary Ocular Adnexal Mucosa-associated Lymphoid Tissue Lymphoma.
10.3341/kjo.2013.27.4.243
- Author:
Won Kyung CHO
1
;
Sung Eun LEE
;
Ji Sun PAIK
;
Seok Goo CHO
;
Suk Woo YANG
Author Information
1. Department of Ophthalmology, Daejeon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Daejeon, Korea.
- Publication Type:Original Article
- Keywords:
Cataract;
Ocular adnexal mucosa-associated lymphoid tissue lymphoma;
Radiotherapy
- MeSH:
Adult;
Aged;
Cataract/*epidemiology/etiology;
Eye Neoplasms/*radiotherapy;
Female;
Follow-Up Studies;
Humans;
Lymphoma, B-Cell, Marginal Zone/*radiotherapy;
Male;
Middle Aged;
*Phacoemulsification;
Radiation Dosage;
Radiotherapy/*adverse effects;
Retrospective Studies;
Risk Factors
- From:Korean Journal of Ophthalmology
2013;27(4):243-248
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To elucidate risk potentiality of frontline radiotherapy associated cataracts in primary ocular adnexal mucosa-associated lymphoid tissue lymphoma (OAML). METHODS: Data from eight consecutive patients of 41 total OAML patients who had undergone cataract surgery after frontline radiotherapy were analyzed. RESULTS: The median patient age was 46 years (range, 36 to 69 years). The median total radiation dose was 3,780 cGy (range, 3,060 to 4,500 cGy), and the mean duration from radiation irradiation to cataract surgery was 36.60 +/- 8.93 months. Preoperative lens opacification was primarily at the posterior lens subcapsule, and best-corrected visual acuity (BCVA) was 0.43 +/- 0.21. Patients underwent the phacoemulsification surgical procedure with posterior chamber intraocular lens insertion. The average BCVA improved to 0.90 +/- 0.14 after cataract surgery. Two patients underwent posterior continuous curvilinear capsulorhexis, and one had posterior capsule rupture. For posterior capsule opacification (PCO), three patients received Nd:YAG laser posterior capsulotomy after the initial surgery, and one patient is currently under consideration for laser posterior capsulotomy. CONCLUSIONS: Radiotherapy increased posterior subcapsule opacification at a relatively young age in primary OAML. Phacoemulsification was a manageable procedure without severe complications, and final visual outcomes were good. However, because after-cataracts progressed earlier than did senile cataracts, close follow-up should be considered for PCO management.
