Immunohistochemical Expression of p53, E-cadherin, and nm23 Proteins in Metastatic Carcinoma of Neck Lymph Node and Corresponding Primary Carcinoma.
- Author:
Jong Kook KIM
;
O Jun KWON
;
Byung Heon KIM
- Publication Type:Original Article
- Keywords:
Metastatic carcinoma;
Neck lymph node;
p53;
E-cadherin;
nm23
- MeSH:
Adenocarcinoma;
Cadherins*;
Carcinoma, Squamous Cell;
Down-Regulation;
Female;
Humans;
Lymph Nodes*;
Neck*;
Neoplasm Metastasis
- From:Korean Journal of Pathology
2000;34(9):615-624
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study was carried out to evaluate the immunohistochemical expressions of p53, E-cadherin, and nm23 proteins in 114 cases of metastatic carcinoma of the neck lymph node (MTLNCA) and corresponding primary carcinoma (PRCA). The positive expressions of p53, E-cadherin, and nm23 proteins were 62.3%, 58.8% and 64.0%, respectively in PRCA, and 40.4%, 38.6%, and 43.9%, respectively in MTLNCA with significant down-regulation from PRCA to MTLNCA (p<0.05). The down-regulation was correlated with female gender, moderate and poor differentiation, and adenocarcinoma in p53 protein, female gender, respiratory and gastrointestinal carcinoma in E-cadherin protein, and female gender, respiratory carcinoma, moderate differentiation, and squamous cell carcinoma in nm23 protein (p<0.05). There was no significant relationship among expressions of p53, E-cadherin, and nm23 proteins (p<0.05). In conclusion, these results suggest that the expressions of p53, E-cadherin, and nm23 proteins seem to be down-regulated from PRCA to MTLNCA and this down-regulation may play a role in invasion and metastasis.
