A Case of Complete Remission of Hairy Cell Leukemia by 2-Chlorodeoxyadenosine.
10.12701/yujm.2004.21.2.237
- Author:
Yong Gil KIM
1
;
Sang Jin LEE
;
Min Kyung KIM
;
Kyung Hee LEE
;
Myung Soo HYUN
;
Hee Sun CHO
Author Information
1. Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Korea. hms@med.yu.ac.kr
- Publication Type:Case Report
- Keywords:
Hairy cell leukemia;
2-chlorodeoxyadenosine;
Complete remission
- MeSH:
Acid Phosphatase;
Adult;
B-Lymphocytes;
Blood Cell Count;
Bone Marrow;
Cladribine*;
Cytoplasm;
Humans;
Immunophenotyping;
Infusions, Intravenous;
Leukemia, Hairy Cell*;
Leukopenia;
Lymphocytes;
Lymphoproliferative Disorders;
Primary Myelofibrosis;
Splenomegaly
- From:Yeungnam University Journal of Medicine
2004;21(2):237-241
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hairy cell leukemia (HCL) is an uncommon chronic B-cell lymphoproliferative disorder that is characterized by cytopenia, splenomegaly, and mononuclear cells displaying cytoplasmic projections. We experienced a case of hairy cell leukemia that developed in a 38-year-old man. He showed marked splenomegaly without palpable lymphoadenopathy. A complete blood cell count revealed leukopenia (3300/microliter with 63% of lymphocyte) and the peripheral blood smear showed abnormal lymphoid cells with cytoplasmic projections. The bone marrow smear revealed abnormal lymphocytes and severe myelofibrosis. Tartrate-resistant acid phosphatase reactivity was strongly positive in the hairy cells. The immunophenotyping results of lymphoid cells were CD5 (-), CD10 (-), CD19 (+), CD25 (+), CD103 (+), CD20 (+), lambda (+). The patient was treated with 2-Chlorodeoxyadenosine at a daily dose of 0.1mg/Kg by a continuous intravenous infusion for 7 days. The patient achieved complete remission.
