A Case of Pituitary Adenoma with Simultaneous Secretion of TSH and GH.
10.3803/EnM.2011.26.2.160
- Author:
Eun Young LEE
1
;
Cheol Ryong KU
;
Hyun Min KIM
;
Woo Kyoung LEE
;
Jung Soo LIM
;
Sena HWANG
;
Do Hwan KIM
;
Dong Yeob SHIN
;
Eun Jig LEE
Author Information
1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. ejlee423@yuhs.ac
- Publication Type:Case Report
- Keywords:
Thyrotropin;
Growth hormone;
Pituitary adenoma
- MeSH:
Adult;
Female;
Floors and Floorcoverings;
Glucose Tolerance Test;
Growth Hormone;
Humans;
Pituitary Hormones, Anterior;
Pituitary Neoplasms;
Rare Diseases;
Reference Values;
Somatostatin;
Stress, Psychological;
Sweat;
Sweating;
Thyroid Function Tests;
Thyrotropin;
Thyroxine;
Weight Loss
- From:Endocrinology and Metabolism
2011;26(2):160-165
- CountryRepublic of Korea
- Language:English
-
Abstract:
Thyrotropin (TSH)-secreting pituitary adenoma is a very rare disease. In one-quarter of patients suffering from this disease, the pituitary tumor secretes other anterior pituitary hormones. Herein, we report a case of pituitary adenoma with simultaneous secretion of TSH and growth hormone (GH). A 34-year-old female visitied local hospital complaining of sweating, intermittent palpitation, and weight loss of 8 kg within 1 year. The patient had undergone trans-sphenoidal surgery 3 years prior for resolution of a TSH and GH co-secreting pituitary adenoma. She had been administered somatostatin analogue prior to visiting our hospital. The patient's GH levels were suppressed to below 1 ng/mL on the 75 g oral glucose tolerance test, and her basal insulin-like growth factor-I (IGF-I) level was within normal range. Thyroid function tests demonstrated increased levels of both free thyroxine and TSH. Sella-MRI revealed pituitary adenoma at the floor of the pituitary fossa, approximately 2 cm in height. Therefore, she was diagnosed with residual TSH-secreting pituitary adenoma. The patient again underwent trans-sphenoidal surgery and entered complete remission, based on hormone levels and MRI findings.
