Vitamin D, and Kidney Disease.
- Author:
Hyung Soo KIM
1
;
Wookyung CHUNG
;
Sejoong KIM
Author Information
- Publication Type:Review
- Keywords: renal insufficiency, chronic; vitamin D; deficiency
- MeSH: Dialysis; Glomerular Filtration Rate; Humans; Kidney; Kidney Diseases; Parathyroid Hormone; Phosphorus; Receptors, Calcitriol; Renal Insufficiency, Chronic; Risk Factors; Vitamin D; Vitamin D Deficiency; Vitamins
- From:Electrolytes & Blood Pressure 2011;9(1):1-6
- CountryRepublic of Korea
- Language:English
- Abstract: Mineral metabolism abnormalities, such as low 1,25-dihydroxyvitamin D (1,25(OH)2D) and elevated parathyroid hormone (PTH), are common at even higher glomerular filtration rate than previously described. Levels of 25-hydroxyvitamin D (25(OH)D) show an inverse correlation with those of intact PTH and phosphorus. Studies of the general population found much higher all-cause and cardiovascular (CV) mortality for patients with lower levels of vitamin D; this finding suggests that low 25(OH)D level is a risk factor and predictive of CV events in patients without chronic kidney disease (CKD). 25(OH)D/1,25(OH)2D becomes deficient with progression of CKD. Additionally, studies of dialysis patients have found an association of vitamin D deficiency with increased mortality. Restoration of the physiology of vitamin D receptor activation should be essential therapy for CKD patients.
