A Case of Acute Isoniazid Intoxication in Childhood.
- Author:
Dong Hyuk KOOK
1
;
Sun Young CHO
;
Kyung Yil LEE
;
In Goo LEE
;
Joon Sung LEE
Author Information
1. Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. leekyungyil@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Isoniazid;
Intoxication;
Child
- MeSH:
Acidosis;
Child;
Coma;
Humans;
Hyperglycemia;
Infant;
Isoniazid*;
Male;
Pyridoxine;
Seizures
- From:
Journal of the Korean Child Neurology Society
2006;14(2):358-362
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Acute isoniazid overdose is a relatively uncommon but potentially life-threatening event. Isoniazid overdose should be suspected in any patient with repeated seizures, coma and metabolic acidosis of uncertain etiology. The effective antidote for acute isoniazid- induced neurotoxicity is known to be pyridoxine. We report a 4-month old boy who showed repeated seizures, coma, metabolic acidosis and hyperglycemia from an accidental isoniazid overdose(100 mg/kg). This boy was recovered completely by the pyridoxine treatment with a dose of equivalent to the amount of isoniazid ingested.
