Development of Urine CRM for the quality Control of Heavy Matal Determinations.
- Author:
Chang Joon PARK
1
;
Kyung Haeng CHO
;
Jeong Kee SUH
Author Information
1. Inorganic Analytical Laboratory, Korea Research Institute of Standards and Science (KRISS), Korea.
- Publication Type:Original Article
- Keywords:
Urine CRM;
GFAAS;
ICP-MS;
Round robin test
- MeSH:
Absorption;
Graphite;
Ion Exchange;
Mass Spectrometry;
Plasma;
Quality Control*;
Songbirds;
Spectrum Analysis
- From:Korean Journal of Occupational and Environmental Medicine
1995;7(2):235-248
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Urine certified reference material (CRM) has been developed to help clinical labolatories control analytical accuracy. Two levels of freeze-dried urine were prepared. The low level CRM was made from normal urine and the abnormal level CRM was prepared by spiking the normal urine with As, Cd, Cr, Cu, Hg, Ni and Pb. Urine reference materials were analyzed by graphite furnace atomic absorption spectrometry (GFAAS) and inductively coupled plasma mass spectrometry (ICP-MS) . Analyte elements were separated from matrix elements by using ion exchange resin and hydride generation. Isotope dilution method was employed to enhance analytical accuracy. Round robin test results are also presented which were carried out with 5 clinical laboratories.
