Neuroendocrine Effects in Occupational Solvents Exposure.
- Author:
Chae Un LEE
1
;
Jong Tae LEE
;
Ui Wha CHUNG
;
Hae Suk SOHN
;
Deog Hwan MOON
;
Jin Ho CHUN
;
Jung Hak KANG
;
Chang Hee LEE
;
Hwi Dong KIM
;
Jong Ham KIM
;
Kui Oak JUNG
Author Information
1. Institution of Industrial Medicine and Department of Preventive Medicine, College of Medicine, Inje University, Korea.
- Publication Type:Original Article
- Keywords:
Neuroendocrine effect;
Occupational solvents exposure
- MeSH:
Axis;
Central Nervous System;
Female;
Follicle Stimulating Hormone;
Growth Hormone;
Humans;
Male;
Occupational Exposure;
Pituitary Hormones;
Plasma;
Solvents*;
Thyrotropin
- From:Korean Journal of Occupational and Environmental Medicine
1995;7(2):362-374
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Long term occupational exposure to solvent mixtures may cause adverse effects to the central nervous system with neurobehavioral symptoms. And some organic solvents have been suggested to cause impairment of tuberoinfundibular dopaminergic activity and neurochemical mechanisms controlling pituitary secretion. For the purpose of assessing neuroendocrine effects in occupational solvents exposure, hormonal study settings (shoes-manufacturing industry & fishing products industry) and compared with nonexposed controls (33men, 85women). Male workers exposed to solvent mixtures had significantly lower plasma level of follicle-stimulating hormone (FSH) than nonexposed male controls. While female workers exposed to solvent mixtures had significantly lower plasma levels of growth hormone (GH), and thyroid-stimulating hormone (TSH) than nonexposed female controls. The results of significant decrease in plasma concentrations of pituitary hormones (FSH, GH, and TSH) in workers exposed solvent mixtures indicate that occupational exposure to solvent mixtures may induce neuroendocrine effects through an effect on hypothalamic pituitary axis.
