Relationship between Bone Mineral Density, Erythropoiesis, and Calcium-Phosphorus-Parathyroid Hormone Status in End-stage Renal Disease Patients.
- Author:
Yoon ju OH
1
;
Seongbin HONG
;
Kyungsun MIN
;
Joon Ho SONG
;
Seung Youn LEE
;
So Hun KIM
;
Moonsuk NAM
;
Yong Seong KIM
Author Information
1. Department of Internal Medicine, Inchon Medical Center, Inchon, Korea.
- Publication Type:In Vitro ; Original Article
- Keywords:
Bone mineral density;
End-stage kidney disease;
Erythropoietin;
Hemoglobins
- MeSH:
Alkaline Phosphatase;
Anoxia;
Body Weight;
Bone Density;
Bone Marrow;
Calcium;
Cross-Sectional Studies;
Dialysis;
Erythropoiesis;
Erythropoietin;
Femur Neck;
Ferritins;
Hemoglobins;
Hip;
Humans;
Iron;
Kidney Failure, Chronic;
Linear Models;
Male;
Mesenchymal Stromal Cells;
Parathyroid Hormone;
Phosphorus;
Spine
- From:Korean Journal of Bone Metabolism
2011;18(2):93-99
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Abnormal bone turnover and mineralization is the characteristic of the end-stage renal disease (ESRD) patients receiving dialysis treatment. Reduced bone mineral density (BMD) has been reported in ESRD patients in many recent studies. Recent study has demonstrated hypoxia increases the loss of bone mass whereas the use of erythropoietin (EPO) increases bone marrow mesenchymal stem cell in vitro, which is the commonly found in ESRD patients. The objective of the present study is to analyze the relationship between erythropoiesis and calcium, phosphorus, parathyroid hormone (PTH) status in ESRD patients. METHODS: This study was a cross-sectional analysis of 183 ESRD patients (78 males, 105 females) on dialysis with mean age of 52 +/- 13 years and mean dialysis duration of 3.4 +/- 3.0 years. Duration and dose of EPO administration, hemoglobin, serum ferritin, and iron were checked in all subjects. BMD was evaluated by DXA. RESULTS: Age was negatively, and body weight and c-calcium positively associated with spine and femur neck and total hip BMD. Hemoglobin was positively correlated with femur neck and total hip BMD. Total dose of EPO, iPTH, and alkaline phosphatase had no significant association with BMD. However, according to tertile of serum PTH concentration, BMD were worst in third tertile group. In multivariate linear regression analysis, age, weight, and serum PTH affect BMD. CONCLUSIONS: BMD was independently related with age and weight. Hemoglobin correlated positively with femur neck and total hip BMD. However, treatment with EPO had no association with BMD. Increased PTH was related with reduced BMD.
