Treatment of Knee Osteoarthritis with Ketoprofen(Ketotop): A Double-blind Placebo-controlled Randomized Trial.
- Author:
Bin YOO
1
;
Seung Won CHOI
;
Moo Song LEE
;
Hee Bom MOON
Author Information
1. Department of Clinical Immunology Asan Medical Center, Ulsan, Seoul, Korea.
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Osteoarthritis;
Knee;
Ketoprofen plaster
- MeSH:
Acetaminophen;
Humans;
Ketoprofen;
Knee*;
Osteoarthritis;
Osteoarthritis, Knee*;
Skin;
Visual Analog Scale
- From:The Journal of the Korean Rheumatism Association
1996;3(1):70-75
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To evaluate the effects of ketoprofen plaster on knee pain in patients with osteoarthritis who are concomittantly treated with acetaminophen. METHODS: Forty-three patints with knee osteoarthritis were randomized into a double-blind, placebo-controlled trial to receive treatment with either placebo or ketoprofen plaster (Ketotop? applied over painful knee for 4 week. The patients were instructed to apply Ketotop%r placebo plaster to more painful knee twice daily. The response to treatment was assessed in I and 4 weeks with the use of visual analog scales (VAS) for pain and a categorical pain scale, and physician's global evaluation. All of the patients continued to receive acetaminophen concomittantly. RESULTS: Significantly more relief of pain was noted in Ketotop treated patients than the placebo treated patients by the end of the study; after four week, Ketotop treated patients demostrated mean reductions in pain of 33%. The reduction in pain was statistically significant in Ketotop group compared with placebo group(p=0.03). According to the physician's global evaluations, 81% of the Ketotop treated patients experienced a reduction in pain after 4 weeks of treatment compared with those treated with placebo(25%o)(p=0.01). No significant adverse effect was noted except mild skin irritation in one case. CONCLUSIONS: The application of Ketotop is a safe and effective adjunctive therapeutic modality for the relief of knee pain in patients with osteoarthritis who are treated with acetaminopen.
