Gestational diabetes insipidus in the third trimester of pregnancy.
- Author:
Su Hee LEE
1
;
Hyun Sun WON
;
Hyun Mee RYU
;
So Young PARK
;
Sung Hoon KIM
;
Ki Ok HAN
;
Hyun Koo YOON
Author Information
1. Cheil General Hospital & Women's Healthcare Center, Division of Endocrinoloy, Kwandong University College of Medicine, Seoul, Korea. hyunkoo.yoon@cgh.co.kr
- Publication Type:Case Report
- Keywords:
Desmopressin;
Gestational diabetes insipidus;
Vasopressinase
- MeSH:
Cystinyl Aminopeptidase;
Deamino Arginine Vasopressin;
Dehydration;
Diabetes Insipidus;
Diabetes, Gestational;
Female;
Fetus;
Humans;
Hypogonadism;
Mitochondrial Diseases;
Mothers;
Ophthalmoplegia;
Polydipsia;
Polyuria;
Pregnancy;
Pregnancy Trimester, Third;
Vasopressins
- From:Korean Journal of Medicine
2009;77(4):512-516
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Gestational diabetes insipidus, which occurs rarely during late pregnancy, may injure the mother and fetus neurologically. It takes place in about 4 of every 100,000 pregnancies. Increased placental-derived vasopressinase in late pregnancy markedly degrades vasopressin. The decreased vasopressin activity causes hypotonic polyuria, polydipsia, and dehydration. We report a woman with gestational diabetes insipidus who had no abnormal laboratory tests before developing symptoms. The diabetes insipidus was controlled well by administering nasal desmopressin (1.desamino.8.D.arginine vasopressin, DDAVP) followed by resolution of the signs and symptoms after delivery. Although gestational diabetes insipidus is rare, a prompt diagnosis and appropriate treatment to reduce the risks of maternal and fetal injury are important.
