Pyridoxine induced neuropathy by subcutaneous administration in dogs.
- Author:
Jin Young CHUNG
1
;
Jung Hoon CHOI
;
Cheol Yong HWANG
;
Hwa Young YOUN
Author Information
- Publication Type:Original Article ; Comparative Study ; Research Support, Non-U.S. Gov't
- Keywords: dog; H-reflex; pyridoxine; sensory neuropathy
- MeSH: Animals; Body Weight/drug effects; *Disease Models, Animal; Dogs; Electrophysiology; Neurodegenerative Diseases/*chemically induced/pathology; Proprioception/drug effects; Pyridoxine/*toxicity
- From:Journal of Veterinary Science 2008;9(2):127-131
- CountryRepublic of Korea
- Language:English
- Abstract: To construct a sensory neuropathy model, excess pyridoxine (150 mg/kg s.i.d.) was injected subcutaneously in dogs over a period of 7 days. During the administrations period, the dogs experienced body weight reduction and proprioceptive loss involving the hindquarters. After pyridoxine administration was completed, electrophysiological recordings showed that the M wave remained at a normal state, but the H-reflex of the treated dogs disappeared at 7 days. The dorsal funiculus of L4 was disrupted irregularly in the axons and myelin with vacuolation. The dorsal root ganglia of L4, and sciatic and tibial nerves showed degenerative changes and vacuolation. However, the lateral and ventral funiculi of L4 showed a normal histopathologic pattern. Although this subcutaneous administration method did not cause systemic toxicity and effectively induced sensory neuropathy, this study confirmed the possibility of producing a pyridoxine-induced sensory neuropathy model in dogs with short-term administration.
