Effects of Some Local Anesthetics on Ca++ Binding to Lipid-Extracted RBC Membrane, Egg Albumin Film and Filter Paper.
- Author:
Johng Suk KIM
1
;
Jong Sik HAH
;
Doo Hee KANG
Author Information
- Publication Type:Original Article
- MeSH: Anesthetics, Local/pharmacology*; Calcium/metabolism*; Cell Membrane Permeability/drug effects; Erythrocytes/cytology*; Filtration; Human; Lidocaine/pharmacology; Ovalbumin/metabolism*; Procaine/pharmacology
- From:Yonsei Medical Journal 1973;14(1):1-9
- CountryRepublic of Korea
- Language:English
- Abstract: Local anesthetics at a concentration of 10 mM(procaine and lidocaine) were found to inhibit competitively Ca++ binding to lipidextracted RBC membrane, and also to egg albumin film fixed on cover glasses or impregnated into Whatman filter paper (No. 1). A competitive inhibition by local anesthetics was also found in Ca++ binding to Whatman filter paper which had been pretreated with organic solvents to extract possible contaminated lipids. Therefore, it is suggested that the local anesthetics inhibit Ca++ binding not only to phospholipids but to some macromolecules such as membrane proteins, egg albumin film and filter paper.
