No Association between PAWR Gene Polymorphisms and Tardive Dyskinesia in Schizophrenia Patients.
- Author:
Il Soo KIM
1
;
Ho Kyoung YOON
;
Seung Gul KANG
;
Young Min PARK
;
Yong Ku KIM
;
Seung Hyun KIM
;
Jung Eun CHOI
;
Leen KIM
;
Heon Jeong LEE
Author Information
1. Department of Psychiatry, Korea University School of Medicine, Seoul, Korea. leehjeong@korea.ac.kr
- Publication Type:Brief Communication
- Keywords:
Schizophrenia;
Tardive dyskinesia;
PAWR;
Polymorphism
- MeSH:
Antipsychotic Agents;
Apoptosis;
Gene Frequency;
Genotype;
Haplotypes;
Humans;
Hyperkinesis;
Movement Disorders;
Polymorphism, Single Nucleotide;
Prostate;
Receptors, Dopamine D2;
Schizophrenia
- From:Psychiatry Investigation
2012;9(2):191-194
- CountryRepublic of Korea
- Language:English
-
Abstract:
Tardive dyskinesia (TD) is a hyperkinetic movement disorder associated with the prolonged use of antipsychotic drugs. Since prostate apoptosis response 4 (Par-4) is a key ligand of the dopamine D2 receptor, the Par-4 gene (PAWR) is a good candidate gene to study in the context of TD susceptibility. We examined the association between PAWR gene polymorphisms and TD. Three single nucleotide polymorphisms of PAWR were selected for the analysis: rs7979987, rs4842318, and rs17005769. Two hundred and eighty unrelated Korean schizophrenic patients participated in this study (105 TD and 175 non-TD patients). Genotype/allele-wise and haplotype-wise analyses were performed. There were no significant differences in genotype and allele frequencies between the two groups. Haplotype analysis also did not reveal a difference between the two groups. Within the limitations imposed by the size of the clinical sample, these findings suggest that PAWR gene variants do not significantly contribute to an increased risk of TD.
