A case of breast cancer in a patient with multiple endocrine neoplasia type 2.
- Author:
Jung Min ROH
1
;
Yoon Bum LEE
;
Hye Rim AN
;
Woo Ho SHIM
;
Eun Hae LEE
;
Soon Won HONG
;
Min Ho CHO
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. noemroem@yuhs.ac
- Publication Type:Case Report
- Keywords:
Breast cancer;
Multiple endocrine neoplasia type 2;
Proto-oncogene protein RET
- MeSH:
Adrenalectomy;
Breast;
Breast Neoplasms;
Carcinoma, Ductal;
Humans;
Hyperplasia;
Multiple Endocrine Neoplasia;
Multiple Endocrine Neoplasia Type 2a;
Pheochromocytoma;
Proto-Oncogene Proteins c-ret;
Thyroid Neoplasms;
Thyroidectomy
- From:Korean Journal of Medicine
2010;79(4):432-437
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Multiple Endocrine Neoplasia Type 2 (MEN2) is a rare hereditary complex disorder characterized by the presence of medullary thyroid carcinoma, pheochromocytoma, and other hyperplasias or neoplasias of different endocrine tissues within a single patient. Simultaneous occurrence of MEN2 and other cancers that are derived from different origins is rare. In this report, we present a patient with known MEN2 who developed breast cancer as a result of invasive ductal carcinoma. The patient underwent total thyroidectomy and unilateral adrenalectomy due to medullary thyroid cancer and pheochromocytoma. Although patients with MEN2 may demonstrate a variety of neoplastic disorders, it is difficult to identify a case report of MEN2 with breast cancer. In addition, no etiological relationships between breast cancer and MEN2 have been reported to date. Thus, here we report a case of known MEN2 with breast cancer and present a review of the literature.
