A 12-year Experience from 1990 to 2001 in Performing Curative Hepatic Resection for Hepatocellular Carcinoma.
- Author:
Moon Won YOO
1
;
Seok Ho CHOI
;
Sung Hwan CHANG
;
Nam Joon YI
;
Kyung Suk SUH
;
Kuhn Uk LEE
Author Information
1. Department of Surgery, Seoul National University College of Medicine, Korea. kulee@plaza.snu.ac.kr
- Publication Type:Original Article
- Keywords:
Hepatocelluar carcinoma (HCC);
Curative hepatic resection
- MeSH:
alpha-Fetoproteins;
Carcinoma, Hepatocellular*;
Child;
Classification;
Disease-Free Survival;
Hepatitis B Surface Antigens;
Humans;
Multivariate Analysis;
Recurrence;
Risk Factors;
Seoul;
Survival Rate
- From:Korean Journal of Hepato-Biliary-Pancreatic Surgery
2002;6(2):138-144
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Hepatic resection is an accepted therapeutic modality for hepatocellular carcinoma (HCC). In the present study, surgical results are analyzed with an aim toward further improving the treatment of HCC. METHODS: We reviewed 831 patients with HCC who underwent a curative hepatic resection in Seoul National University Hospital from 1990 to 2001. We analyzed age, sex, GOT/ GPT, alpha-fetoprotein (alpha FP), HBsAg, anti-HCV, Child classification, size and number of tumor, extent of resection, resection margin, and perioperative transfusion. RESULTS: 1-, 3-, and 5-year overall survival rates were 91.1%, 79.8%, and 71.7%. 1-, 3-, and 5-year disease-free survival rates were 66.9%, 39.3%, and 29.8%. Risk factors of multivariate analysis of recurrence were GOT (>40 IU/L), alpha FP (>20 ng/dl), Child classification (B and C), tumor number (> or =2), tumor size (>5 cm), and extent of resection (major hepatectomy). Prognostic factors of multivariate analysis of overall survival rate were GOT, tumor number, and extent of resection. CONCLUSION: Although the recurrence rate is still high, identifying an individual patient who is at risk of tumor recurrence (GOT>40 IU/L, alpha FP>20 ng/dl, Child B and C, tumor number> or =2, tumor size >5 cm, and major hepatectomy) is helpful to estimate disease-free survival.
