The Effect of Intravitreal Melatonin on Rabbit Retina.
- Author:
Do Gyun KIM
1
;
Won Sup SOHN
;
Hyung Woo KWAK
Author Information
1. Department of Ophthalmology, College of Medicine, KyungHee University, Korea. hwkwak@khmc.or.kr
- Publication Type:Original Article
- Keywords:
Antioxidant;
Free radical scavenger;
Intravitreal injection;
Melatonin;
Retinal toxicity
- MeSH:
Dimethyl Sulfoxide;
Edema;
Intravitreal Injections;
Melatonin*;
Retina*
- From:Journal of the Korean Ophthalmological Society
2002;43(9):1781-1788
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To investigate the effect of intravitreal melatonin on retina in rabbit. METHODS: In four pigmented rabbit, melatonin was intravitreally injected 100 mu g/0.1 ml, 300 mu g/0.1 ml concentration in left eye, DMSO was injected in right eye as control. we examined gross fundus finding and electroretinogram and then light and electronic microscopic findings at 24 hours and 1 week with both eye. RESULTS: intravitreally melatonin injected eye at 100 mu g/0.1 ml, 300 mu g/0.1 ml concentration and control eye at 1 day and 1 week, significant difference was not shown in gross fundus finding, electroretinogram, light and electronic microscopic finding. Additionally edema, toxic effect change was not found in retina. CONCLUSIONS: Intravitreally injected melatonin has not influenced on retina grossly, histologically, physiologically at 100 mu g/0.1 ml and 300 mu g/0.1 ml concentration. Further study is required about toxic effect of melatonin over 300 mu g/0.1 ml concentration and clinical usefulness of melatonin in retina.
