The clinicopathological relationship of E2F-1 and Ki-67 expression in endometrial cancer.
- Author:
Hye In CHONG
1
;
Yun Ji BAEK
;
Ho Jin JANG
;
Dong Soo SUH
;
Man Soo YOON
;
Kyung Un CHOI
Author Information
1. Department of Obstetrics & Gynecology, College of Medicine, Pusan National University, Busan, Korea. msyoon@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
Endometrial cancer;
E2F-1;
Ki-67
- MeSH:
Endometrial Neoplasms;
Female;
Hysterectomy;
Lymph Nodes;
Neoplasm Metastasis;
Retrospective Studies
- From:Korean Journal of Obstetrics and Gynecology
2009;52(2):228-236
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The aim of this study was to evaluate the correlation of E2F-1 and Ki-67 expression with clinicopathological prognostic factors. METHODS: Retrospectively, endometrial cancer slide samples (n=71) were analyzed. E2F-1 and Ki-67 were evaluated using immunohistochemical staining. And as a control (n=21), endometrial tissues were obtained by hysterectomy with benign gynecologic disease. RESULTS: Of 71 cases, the positive E2F-1 expression was 53.5% (38/71) in endometrial cancer. The expression of E2F-1 showed a remarkable positive correlation with myometrial invasion (P=0.001) and lymphovascular invasion (P=0.000). The Ki-67 labeling index was 30.56+/-25.67 in endometrial cancer and 9.38+/-8.35 in normal endometrial tissues (P=0.001). The Ki-67 labeling index showed positive correlations with increased tumor size (P=0.046, gamma=0.238), positive lymph node metastasis (P=0.001, gamma=0.396), cervical invasion (P=0.000, gamma=0.404) and lymphovascular tumor invasion (P=0.000, gamma=0.597). There was a positive correlation between E2F-1 and Ki-67 expression (P=0.000, gamma=0.734). CONCLUSION: The Ki-67 expression seems to be related with tumor invasiveness and growth in endometrial cancer and shows a remarkable positive correlation with E2F-1. The E2F-1 expression seems to be not related as a direct prognostic factor but related with tumor invasiveness and growth in endometrial cancer.
