The trend in the eradication rates of first- and second-line therapy for Helicobacter pylori infection in Daegu and Kyungpook provinces: a single center experience for the most recent 9 years.
- Author:
Han Jin CHO
1
;
Rack Cheon BAE
;
Soon Hak LEE
;
Sun Ik JANG
;
Hyun Seok LEE
;
So Young CHOI
;
Keun Young SHIN
;
Jun HEO
;
Sung Kook KIM
;
Min Kyu JUNG
;
Seong Woo JEON
Author Information
1. Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea. swjeon@knu.ac.kr
- Publication Type:Original Article
- Keywords:
Helicobacter pylori;
First-line regimen;
Eradication rates
- MeSH:
Drug Resistance, Microbial;
Helicobacter;
Helicobacter pylori;
Humans;
Korea;
Prevalence;
Retrospective Studies;
Ulcer
- From:Korean Journal of Medicine
2009;76(2):186-192
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: The reported prevalence of antibiotic resistance in Helicobacter pylori infection has been increasing. However, recent trends in the eradication rates of H. pylori using first-line triple regimens are rarely reported. Therefore, we determined the trend in the H. pylori eradication rates in a single center for the most recent 9 years in Daegu and Kyungpook provinces, Korea. METHODS: From January 1999 through December 2007, the eradication rates in 615 H. pylori-positive patients who received one-week triple regimens were evaluated retrospectively according to year and ulcer location. RESULTS: The overall H. pylori eradication rate was 81.6%. The eradication rate from the years 1999 to 2007 was 76.3, 78.3, 82.8, 88.5, 77.8, 91.7, 84.8, 75.4, and 83.7%, respectively, based on the per-protocol analysis. No definite evidence of a decreasing tendency of the eradication rate was seen over the 9 years (p=0.760). Furthermore, there was no significant difference in the eradication rate according to ulcer location. CONCLUSIONS: There is no decreasing trend in the H. pylori eradication rate over the past 9 years in Daegu and Kyungpook provinces. However, the eradication rates are not satisfactory, and further investigation is needed to develop more effective regimens.
