Comparison of the Efficacy of Antibiotic Monotherapy and Antibiotic Plus Alpha-blocker Combination Therapy for Patients with Inflammatory Chronic Prostatitis/Chronic Pelvic Pain Syndrome.
- Author:
Chul Woong YOUN
1
;
Kyung Chul SON
;
Hyang Sik CHOI
;
Dong Deuk KWON
;
Kwangsung PARK
;
Soo Bang RYU
Author Information
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords: Prostatitis; Pelvic pain; Adrenergic alpha-blockers; Antibiotics
- MeSH: Academies and Institutes; Adrenergic alpha-Antagonists; Anti-Bacterial Agents; Fluoroquinolones; Humans; Massage; Pelvic Pain; Prostatitis; Quality of Life; Urinalysis
- From:Korean Journal of Urology 2008;49(1):72-76
- CountryRepublic of Korea
- Language:Korean
- Abstract: PURPOSE: The objectives of this study was to compare the efficacy of antibiotic monotherapy with antibiotic plus alpha-blocker combination therapy for the treatment of inflammatory chronic pelvic pain syndrome (CPPS) patients. MATERIALS AND METHODS: Between October 2005 and May 2006, 69 patients who were diagnosed as CPPS(National Institutes of Health; NIH-catagory IIIa), were included in this study. The patients were randomly placed into two groups: group I was treated with gatifloxacin alone(35 patients), and group II was treated with gatifloxacin and doxazosin(34 patients) for 6 weeks. For all the patients, the urinalysis, expressed prostatic massage, the National Institute of Health-Chronic Prostatitis Symptom Index(NIH-CPSI) and a distal rectal examination(DRE) were performed at the initial visit. The NIH-CPSI was compared both before and after the treatment. RESULTS: On the initial diagnosis, the mean CPSI of the group I patients was 24.0+/-6.3, and that for the group II patients was 24.7+/-6.9. After the treatment, that of the group I was 16.6+/-5.4, and that of group II was 13.4+/-5.3. After 6 weeks of treatment, the changes in the total CPSI scores had significantly improved in group II compared with group I(p<0.05). A statistically significant improvement occurred in the pain score, the voiding symptom score and the quality of life in the group II compared with group I(p<0.05) CONCLUSIONS: This study suggests that combination therapy of antibiotic plus alpha-blocker would be more effective than antibiotic monotheraphy for treating patients with inflammatory chronic prostatitis/chronic pelvic pain syndrome.
