Interleukin-32 in Inflammatory Autoimmune Diseases.
- Author:
Soohyun KIM
1
Author Information
- Publication Type:Review
- Keywords: Cytokine; Inflammatory diseases; Inflectional immune responses; Immune cell differentiation; Inflammatory cancer
- MeSH: Animals; Arthritis, Rheumatoid; Autoimmune Diseases*; Clone Cells; Cytokines; Inflammatory Bowel Diseases; Interleukin-6; Lung Diseases; Mammals; Mice; Rodentia; T-Lymphocytes; Tumor Necrosis Factor-alpha; Vascular Diseases
- From:Immune Network 2014;14(3):123-127
- CountryRepublic of Korea
- Language:English
- Abstract: Interleukin-32 (IL-32) is a cytokine inducing crucial inflammatory cytokines such as tumor necrosis factor-alpha (TNFalpha) and IL-6 and its expression is elevated in various inflammatory autoimmune diseases, certain cancers, as well as viral infections. IL-32 gene was first cloned from activated T cells, however IL-32 expression was also found in other immune cells and non-immune cells. IL-32 gene was identified in most mammals except rodents. It is transcribed as multiple-spliced variants in the absence of a specific activity of each isoform. IL-32 has been studied mostly in clinical fields such as infection, autoimmune, cancer, vascular disease, and pulmonary diseases. It is difficult to investigate the precise role of IL-32 in vivo due to the absence of IL-32 gene in mouse. The lack of mouse IL-32 gene restricts in vivo studies and restrains further development of IL-32 research in clinical applications although IL-32 new cytokine getting a spotlight as an immune regulatory molecule processing important roles in autoimmune, infection, and cancer. In this review, we discuss the regulation and function of IL-32 in inflammatory bowel diseases and rheumatoid arthritis.
