Immunohistochemical Study of PCNA(Proliferating Cell Nuclear Antigen) in Pterygium.
- Author:
Jin Bea MIN
1
;
Yong Suk CHOI
;
Ji Young KIM
Author Information
1. Department of Ophthalmology, College of Medicine, Chungbuk National University.
- Publication Type:Original Article
- Keywords:
Cellular proliferation;
Epithelium;
Fibroblast;
Proliferating cell nuclear antigen;
Pterygium
- MeSH:
Cell Proliferation;
Conjunctiva;
Connective Tissue;
Epithelial Cells;
Epithelium;
Fibroblasts;
Paraffin;
Proliferating Cell Nuclear Antigen;
Pterygium*
- From:Journal of the Korean Ophthalmological Society
1999;40(1):70-74
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To investigate cellular proliferation pattern of pterygial tissue, eleven paraffin sections through two normal conjunctiva, six primary and three recurrent pterygia were studied immunohistochemically by finding epithelial cells and subepithelial fibroblasts staining patterns as defined by monoclonal antibody for proliferating cell nuclear antigen(PCNA). The results showed similar epithelial cellular proliferation patterns in normal conjunctiva, primary and recurrent pterygia. But scattered patches of fibroblasts in subepithelial connective tissue staining positive with PCNA were found only in recurrent pterygium. Our results suggest that primary pterygium is not a disorder of excess cellular proliferation, but a proliferation of fibroblasts in subepithelial connective tissue have a role in pathogenesis of recurrent pterygium.
