Serum neuron specific enolase is increased in pediatric acute encephalitis syndrome.
10.3345/kjp.2017.60.9.302
- Author:
Dian PRATAMASTUTI
1
;
Prastiya INDRA GUNAWAN
;
Darto SAHARSO
Author Information
1. Post Graduate PhD Program, College of Medicine, Airlangga University, Surabaya, Indonesia.
- Publication Type:Original Article
- Keywords:
Acute encephalitis syndrome;
Neuron specific enolase;
Child
- MeSH:
Body Temperature;
Brain Injuries;
Child;
Encephalitis*;
Glasgow Coma Scale;
Hemodynamics;
Humans;
Neurology;
Neurons*;
Observational Study;
Phosphopyruvate Hydratase*;
Prospective Studies;
Seizures, Febrile;
Status Epilepticus
- From:Korean Journal of Pediatrics
2017;60(9):302-306
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: This study aimed to investigate whether serum neuron-specific enolase (NSE) was expressed in acute encephalitis syndrome (AES) that causes neuronal damage in children. METHODS: This prospective observational study was conducted in the pediatric neurology ward of Soetomo Hospital. Cases of AES with ages ranging from 1 month to 12 years were included. Cases that were categorized as simple and complex febrile seizures constituted the non-AES group. Blood was collected for the measurement of NSE within 24 hours of hemodynamic stabilization. The median NSE values of both groups were compared by using the Mann-Whitney U test. All statistical analyses were performed with SPSS version 12 for Windows. RESULTS: In the study period, 30 patients were enrolled. Glasgow Coma Scale mostly decreased in the AES group by about 40% in the level ≤8. All patients in the AES group suffered from status epilepticus and 46.67% of them had body temperature >40℃. Most of the cases in the AES group had longer duration of stay in the hospital. The median serum NSE level in the AES group was 157.86 ng/mL, and this value was significantly higher than that of the non-AES group (10.96 ng/mL; P<0.05). CONCLUSION: AES cases showed higher levels of serum NSE. These results indicate that serum NSE is a good indicator of neuronal brain injury.
