The Change of Prostate Specific Antigen after Treatment in Chronic Prostatitis Associated with Elevated Serum Prostate Specific Antigen.
- Author:
Joo Yeol CHEONG
1
;
Sang Hyeon CHEON
;
Ro Jung PARK
;
Chang Soo OH
;
Jung Hyun KIM
Author Information
1. Department of Urology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea. arlef@uuh.ulsan.kr
- Publication Type:Original Article
- Keywords:
Prostate specific antigen;
Prostatitis
- MeSH:
Anti-Bacterial Agents;
Biopsy;
Follow-Up Studies;
Humans;
Male;
Medical Records;
Prostate*;
Prostate-Specific Antigen*;
Prostatic Hyperplasia;
Prostatic Neoplasms;
Prostatitis*;
Retrospective Studies
- From:Korean Journal of Urology
2003;44(8):819-822
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Men with documented chronic prostatitis, with elevated serum prostate specific antigen (PSA), were investigated to assess whether treatment lowers serum PSA and thus avoids unnecessary biopsies. MATERIALS AND METHODS: The medical records of 46 men who presented with serum PSA higher than 4ng/ml, and subsequently diagnosed with chronic prostatitis, were retrospectively reviewed. After the administration of antibiotics and anti-inflammatory drugs for 4 to 8 weeks, the follow-up PSA levels were determined, and those with levels higher than 4ng/ml underwent a prostate biopsy. RESULTS: The mean PSA level decreased 61% from 11.66ng/ml before, to 3.79ng/ml after, treatment (p<0.001). In 30 patients the serum PSA level decreased to below 4ng/ml (mean 1.69), with these patients no longer having an indication for a prostate biopsy. In the remaining 16 patients the serum PSA level remained elevated above 4ng/ml, so they underwent a prostate biopsy. Pathological study revealed benign prostatic hyperplasia in 11 cases and prostate cancer in 5. The PSA level in patients associated with benign prostatic hyperplasia decreased 61.9% with treatment, from 19.96 to 7.88ng/ml (p=0.006) and the PSA in those associated with prostate cancer decreased 30.6% with treatment, from 12.85 to 7.32ng/ml (p<0.05). CONCLUSIONS: This study demonstrates that chronic prostatitis can cause elevation of serum PSA levels, and when identified, antibiotics and anti-inflammatory treatment can lower these levels and an unnecessary prostate biopsy can be avoided.
