Association of Serum Gamma Glutamyltransferase and Fasting Blood Glucose among Middle Aged and Elderly in Chuncheon: Hallym Aging Study.
10.4082/kjfm.2009.30.1.23
- Author:
Jung Su LIM
1
;
Young Ho CHOI
;
Jin Young JEONG
;
Soong Nang JANG
;
Yoo Sun MOON
;
Jung Hun KIM
;
Eun Shin KWAK
;
Moon Gi CHOI
;
Kyung Soon HONG
;
Dong Hyun KIM
Author Information
1. Department of Family Medicine, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, Korea.
- Publication Type:Original Article
- Keywords:
Gamma-Glutamyltransferase;
Impaired Fasting Glucose;
Insulin Resistance
- MeSH:
Adult;
Aged;
Aging;
Blood Glucose;
Body Mass Index;
Cardiovascular Diseases;
Cross-Sectional Studies;
Fasting;
Female;
gamma-Glutamyltransferase;
Glucose;
Humans;
Insulin Resistance;
Male;
Middle Aged;
Odds Ratio;
Plasma;
Reference Values;
Risk Factors
- From:Korean Journal of Family Medicine
2009;30(1):23-30
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Serum gamma-glutamyltransferase (GGT) was reported to be associated with type 2 diabetes, various cardiovascular disease risk factors, and individual components of metabolic syndrome. We performed a cross-sectional study to elucidate the relations between GGT and impaired fasting glucose (IFG). METHODS: The subject of this study included 693 adults (males 272, females 421) aged 45 years or over who have lived in Chuncheon, a suburban small-sized city. IFG was defined as elevated fasting plasma glucose (FPG) concentration of > or = 100 and < 126 mg/dl. RESULTS: The risk of IFG appeared to increase with increasing levels of serum GGT even after adjusting for other covariates, such as body mass index and inflammatory markers among men only: adjusted odds ratios of IFG across GGT categories (< 25th, < 50th, < 75th and > or = 75th) were 1.0, 0.56, 1.57, and 2.79, respectively (P-value for trend 0.022). In women, the association between the risk of IFG and GGT was not statistically significant. CONCLUSION: This study suggests that elevated level of GGT within the normal range is an independent predictor of impaired fasting glucose in middle-aged or older men but not in women.
