Induction of antibody and interferon-gamma production in mice immunized with virus-like particles of swine hepatitis E virus.
10.4142/jvs.2014.15.4.575
- Author:
Young Jo SONG
1
;
Woo Jung PARK
;
Seul Kee LEE
;
Joong Bok LEE
;
Seung Yong PARK
;
Chang Seon SONG
;
Sang Won LEE
;
Kun Ho SEO
;
Young Sun KANG
;
Jae Young SONG
;
In Soo CHOI
Author Information
1. Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea. ischoi@konkuk.ac.kr
- Publication Type:Brief Communication ; Research Support, Non-U.S. Gov't
- Keywords:
interferon-gamma;
swine hepatitis E virus;
virus-like particle
- MeSH:
Animals;
Antibodies, Viral/blood;
Capsid Proteins/immunology;
Female;
Hepatitis E/immunology/*veterinary/virology;
Hepatitis E virus/*immunology;
Immunization/*veterinary;
Interferon-gamma/blood;
Mice;
Mice, Inbred BALB C;
Swine;
Swine Diseases/*immunology/virology;
Vaccines, Virus-Like Particle/immunology;
Viral Hepatitis Vaccines/*immunology
- From:Journal of Veterinary Science
2014;15(4):575-578
- CountryRepublic of Korea
- Language:English
-
Abstract:
Virus-like particles (VLPs) composed of the truncated capsid protein of swine hepatitis E virus (HEV) were developed and immune responses of mice immunized with the VLPs were evaluated. IgG titers specific for the capsid protein of swine HEV were significantly higher for all groups of mice immunized with the VLPs than those of the negative control mice. Splenocytes from mice immunized with the VLPs also produced significantly greater quantities of interferon (IFN)-gamma than interleukin (IL)-4 and IL-10. These newly developed swine HEV VLPs have the capacity to induce antigen-specific antibody and IFN-gamma production in immunized mice.
