Detection of Corynebacterium bovis infection in athymic nude mice from a research animal facility in Korea.
10.4142/jvs.2014.15.4.583
- Author:
Tae Hyoun KIM
1
;
Dong Su KIM
;
Ju Hee HAN
;
Seo Na CHANG
;
Kyung Sul KIM
;
Seung Hyeok SEOK
;
Dong Jae KIM
;
Jong Hwan PARK
;
Jae Hak PARK
Author Information
1. Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea. pjhak@snu.ac.kr
- Publication Type:Case Reports ; Research Support, Non-U.S. Gov't
- Keywords:
athymic nude mice;
Corynebacterium bovis;
hyperkeratosis
- MeSH:
Animals;
Corynebacterium/*isolation & purification;
Corynebacterium Infections/*microbiology/pathology;
*Mice;
Mice, Nude;
Polymerase Chain Reaction/veterinary;
RNA, Ribosomal, 16S/genetics;
Republic of Korea;
Rodent Diseases/*microbiology/pathology;
Skin Diseases, Bacterial/*microbiology/pathology
- From:Journal of Veterinary Science
2014;15(4):583-586
- CountryRepublic of Korea
- Language:English
-
Abstract:
Corynebacterium (C.) bovis infection in nude mice causes hyperkeratosis and weight loss and has been reported worldwide but not in Korea. In 2011, nude mice from an animal facility in Korea were found to have white flakes on their dorsal skin. Histopathological testing revealed that the mice had hyperkeratosis and Gram-positive bacteria were found in the skin. We identified isolated bacteria from the skin lesions as C. bovis using PCR and 16S rRNA sequencing. To the best of our knowledge, this is the first report of C. bovis infection in nude mice from Korea.
