Association among C-Reactive Protein, Pulse Pressure and Ischemic Heart Disease in Patients with Continuous Ambulatory Peritoneal Dialysis.
- Author:
Jeong Ik LEE
1
;
Soon Kil KWON
;
Sang Hyun KIM
;
Jang Won SEO
;
Jai Won CHANG
;
Soon Bae KIM
;
Sang Koo LEE
;
Jung Sik PARK
Author Information
1. Department of Internal Medicine, College of Medicine, University of Ulsan, Seoul, Korea. sbkim@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
C-reactive protein;
Pulse pressure;
Coronary heart disease;
CAPD
- MeSH:
Adult;
Blood Pressure*;
Body Mass Index;
C-Reactive Protein*;
Cardiovascular Diseases;
Cholesterol;
Coronary Artery Disease;
Coronary Disease;
Dialysis;
Fibrinogen;
Humans;
Hypertension;
Lipoprotein(a);
Logistic Models;
Male;
Mortality;
Myocardial Ischemia*;
Peritoneal Dialysis, Continuous Ambulatory*;
Risk Factors;
Smoke;
Smoking;
Thallium;
Tomography, Emission-Computed, Single-Photon;
Vascular Diseases
- From:Korean Journal of Nephrology
2003;22(1):102-108
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Atherosclerotic vascular disease is the major cause of morbidity and mortality in dialysis patients. C-reactive protein (CRP) appears to be clinically useful in prediction of coronary heart disease. Elevated pulse pressure has been associated with an increased risk of cardiovascular disease among apparently healthy adults. Therefore, we evaluated the association between a persistent elevation of C-reactive protein level, pulse pressure and the presence of ischemic heart disease in patients with continuous ambulatory peritoneal dialysis (CAPD). METHODS: A total of 71 CAPD patients (42 males, 29 females) who underwent thallium SPECT and followed up more than 6 months were included. We collected the data about age, sex, smoking, diabetes, hypertension, pulse pressure and body mass index. Blood levels of albumin, total cholesterol, fibrinogen, lipoprotein (a) and C-reactive protein were measured. RESULTS: The values of C-reactive protein, pulse pressure, smoking and fibrinogen were significantly higher in thallium SPECT positive group (p<0.05). A 0.01 mg/dL increase in C-reactive protein was associated with a 1.014 increase in the odds of having an elevated risk of coronary artery disease (95% confidence interval 1.008-1.019) and a 1 mmHg increase in pulse pressure was associated with a 1.017 increase in the odds of having an elevated risk of coronary artery disease (95% confidence interval 1.011-1.023). By multivariate logistic regression analysis, C-reactive protein and pulse pressure were independent risk factors for ischemic heart disease. Log CRP level was positively correlated with pulse pressure level (p<0.01). CONCLUSION: The baseline level of CRP and pulse pressure independently predicts the risk of coronary heart disease in CAPD patients. For patients who have a persistent elevation of CRP and pulse pressure without an apparent cause, we recommend a workup for ischemic heart disease.
