A Case of Fanconi's Syndrome Due to Chinese Herb Nephropathy: Differences between European and Asian CHN.
- Author:
Chang Ryeol CHOI
1
;
Yeo Wook YUN
;
Dong Kyu LEE
;
Jae Myun JUNG
;
Taeck Won HONG
;
Sang Woong HAN
;
Seung Sam PAIK
;
Moon Hyang PARK
;
Ho Jung KIM
Author Information
1. Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea. kimhj@hanyang.ac.kr
- Publication Type:Case Report
- Keywords:
Chinese Herb Nephropathy;
Interstitial nephritis;
Fanconi's syndrome;
Aristolochic acid
- MeSH:
Asia;
Asian Continental Ancestry Group*;
Belgium;
Continental Population Groups;
Digestion;
Humans;
Korea;
Male;
Nephritis, Interstitial;
Prevalence;
Renal Insufficiency
- From:Korean Journal of Nephrology
2003;22(1):118-123
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We encountered one case of Chinese Herb Nephropathy in Korea. But clinical feature of our case was different from those of CHN in Belgium. The purpose of this case report was clarified the features of CHN in Asia. The subjects consisted of a patient diagnosed as interstitial nephritis in Hanyang University Hospital and of those reported in the literature in Asia and Belgium. We investigated the clinical and histological features of CHN patients in Asia and compared them with the Belgian cases. The remarkable differences were as follows; (1) relatively high prevalence in males compared with Belgian cases, (2) digestion with multiple object and mode in Asia, (3) Most of renal failure in Asia were improved or were in stable status. (4) Fanconi's syndrome was found in most cases of Asia. In conclusion, CHN in Asia has some characteristics distinguished from Belgian Chinese Hreb Nephropathy. These findings could indicate that susceptibility to aristolochic acid may be different among races. Furthermore, it is likely that different components of AA could cause different features, that the amount of ingested AA, mode in digestion, or interaction with other components except nephrotoxic agent such as AA might reflect clinical pictures. Other hypothesis may be some other toxic substances affecting the clinical findings although they are not identified at present. Further studies must be undertaken to clarify these differences.
