A Case of Anti-Glomerular Basement Membrane Antibody Disease without Pulmonary Hemorrhage.
- Author:
Sun Gyo LIM
1
;
Jeong Eun KIM
;
Jong Woo LEE
;
Dong Hun LEE
;
Seung Kwan LIM
;
In Whee PARK
;
Hyeon Kyeong CHO
;
Heungsoo KIM
;
Gyu Tae SHIN
;
Hyun Ee LIM
Author Information
1. Department of Nephrology, Ajou University School of Medicine, Suwon, Korea. nephrohs@ajou.ac.kr
- Publication Type:Case Report
- Keywords:
Anti-glomerular basement membrane antibody disease;
Crescent;
Plasmapheresis;
Corticosteroid
- MeSH:
Antibodies;
Autoimmune Diseases;
Basement Membrane*;
Biopsy;
Capillaries;
Edema;
Enzyme-Linked Immunosorbent Assay;
Glomerular Basement Membrane;
Glomerulonephritis;
Hematuria;
Hemorrhage*;
Immunoglobulin G;
Plasmapheresis;
Renal Dialysis;
Urinalysis
- From:Korean Journal of Nephrology
2003;22(1):142-147
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Anti-glomerular basement membrane antibody mediated rapidly progressive glomerulonephritis is a rare autoimmune disease. It is characterized by acuterenal failure and crescentic glomeruli with linear immune deposits along glomerular basement membrane mediated by anti-GBM antibodies. We report a case of a sixty-years-old man with generalized edema and hematuria. On admission, BUN/Creatinine was 118/19.6 mg/dL, Hb was 10.2 g/dL. On urinalysis, protein was 3+, and many RBCs were found. Renal biopsy specimen which contained 8 glomeruli showed active cellular crescent formation in all glomeruli. On immunofluorescent staining specimen, there were 4 glomeruli which showed strong IgG linear staining along the glomerular basement membrane and mild C3 & C1q deposit along the capillary walls. The titer of anti-GBM antibody was 123 EU by ELISA (normal: <10 EU). We treated with high dose of corticosteroid and plasmapheresis, but renal function was not recovered even after 3 months of hemodialysis.
