Prognostic Significance of E-cadherin Expression in Renal Cell Carcinoma.
- Author:
Tae Hyoung KIM
1
;
Kyung Keun SEO
;
Young Sun KIM
Author Information
1. Department of Urology, Chung-Ang University, Seoul, Korea.
- Publication Type:In Vitro ; Original Article
- Keywords:
renal cell carcinoma;
prognosis;
E-cadherin;
immunohistochemical staining
- MeSH:
Cadherins*;
Carcinoma, Renal Cell*;
Cell Adhesion Molecules;
Disease-Free Survival;
Humans;
Prognosis
- From:Korean Journal of Urology
1996;37(11):1221-1226
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
E-cadherin is one of intercellular adhesion molecules, and it has been demonstrated that E- cadhedrin acts as an invasion suppressor in vitro and loss of its expression is an important prognostic factor in human malignancies. However the prognostic value of loss of expression of E-cadhedrin in renal cell carcinoma (RCC) remains to be defined. We herein immunohistochemically examined the expression of E-cadhedrin in paraffin- embedded tissues of 43 patients with RCC to investigate the prognostic value of loss of expression of E-cadherin. Twenty three of 43 patients (54.5%) showed loss of expression of E- cadherin. There were significant correlations between loss of expression of E-cadherin and histopathologic grade, Robson stage, T stage, N stage and M stage (all p<0.05). Patients with loss of expression of E-cadherin showed significantly decreased 2 year disease free survival as compared with those with normal expression of E-cadherin (p<0.001). These results suggest that loss of expression of E-cadherin has a ominous prognostic value in patients with RCC.
