Serum Elastin-Derived Peptides and Anti-Elastin Antibody in Patients with Systemic Sclerosis.
10.3346/jkms.2012.27.5.484
- Author:
Yoo Jin HONG
1
;
Jinhyun KIM
;
Bo Ram OH
;
Yun Jong LEE
;
Eun Young LEE
;
Eun Bong LEE
;
Seung Hyo LEE
;
Yeong Wook SONG
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. ysong@snu.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Elastin;
Elastin-Derived Peptide;
Systemic Sclerosis
- MeSH:
Adult;
Antibodies, Anti-Idiotypic/*blood/immunology;
Centromere/immunology;
Elastin/*blood/immunology;
Enzyme-Linked Immunosorbent Assay;
Female;
Humans;
Male;
Middle Aged;
Peptides/*blood/immunology;
Scleroderma, Systemic/*metabolism/pathology
- From:Journal of Korean Medical Science
2012;27(5):484-488
- CountryRepublic of Korea
- Language:English
-
Abstract:
The elastin metabolism in systemic sclerosis (SSc) has been known to be abnormal. The authors investigated relationship between the clinical manifestations of systemic sclerosis (SSc) and serum levels of soluble elastin-derived peptide (S-EDP) and anti-elastin antibodies. Serum samples were obtained from 79 patients with SSc and 79 age- and sex-matched healthy controls. Concentrations of serum S-EDP and anti-elastin antibodies were measured by ELISA. The serum concentrations of S-EDP in SSc patients were significantly higher than in healthy controls (median, 144.44 ng/mL vs 79.59 ng/mL, P < 0.001). Serum EDP concentrations were found to be correlated with disease duration in SSc (P = 0.002) and particularly in diffuse cutaneous SSc (P = 0.005). Levels of anti-elastin antibodies were found to be more elevated in SSc patients than in healthy controls (median, 0.222 U vs 0.191 U, P = 0.049), more increased in diffuse cutaneous SSc than limited cutaneous SSc (median, 0.368 U vs 0.204 U, P = 0.031). In addition, levels of anti-elastin antibodies were also found to be negatively associated with presence of anti-centromere antibody (P = 0.023). The S-EDP levels were not found to be correlated with levels of anti-elastin antibodies. The increased S-EDP and anti-elastin antibody levels and association with clinical and laboratory characteristics may reflect the abnormal metabolism in SSc.
