A Rare Case of Primary Hyperparathyroidism Associated with Primary Aldosteronism, Hurthle Cell Thyroid Cancer and Meningioma.
10.3346/jkms.2012.27.5.560
- Author:
You Lim KIM
1
;
Young Woo JANG
;
Jin Taek KIM
;
Su Ah SUNG
;
Tae Seok LEE
;
Won Mi LEE
;
Hyo Jeong KIM
Author Information
1. Department of Internal Medicine, Eulji University School of Medicine, Seoul, Korea. kimhj@eulji.ac.kr
- Publication Type:Case Reports
- Keywords:
Hyperparathyroidism;
Primary Hyperaldosteronism;
Thyroid Cancer, Hurthle-cell;
Meningioma
- MeSH:
Aged;
Base Sequence;
Brain/radionuclide imaging;
Female;
Humans;
Hyperaldosteronism/complications/*diagnosis;
Hyperparathyroidism, Primary/*diagnosis/etiology/pathology;
Loss of Heterozygosity;
Magnetic Resonance Imaging;
Meningeal Neoplasms/complications/*diagnosis/radionuclide imaging;
Meningioma/complications/*diagnosis/radionuclide imaging;
Mutation;
Parathyroid Glands/pathology;
Proto-Oncogene Proteins/genetics/metabolism;
Sequence Analysis, DNA;
Thyroid Neoplasms/complications/*diagnosis/pathology;
Tomography, X-Ray Computed
- From:Journal of Korean Medical Science
2012;27(5):560-564
- CountryRepublic of Korea
- Language:English
-
Abstract:
Multiple endocrine neoplasia type 1 (MEN1) syndrome includes varying combinations of endocrine and non-endocrine tumors. There are also a considerable number of atypical MEN1 syndrome. In this case, a 68-yr-old woman was referred to the Department of Endocrinology for hypercalcemia. Five years ago, she had diagnosed as primary hyperaldosteronism and now newly diagnosed as parathyroid hyperplasia with laboratory and pathologic findings. Hurthle-cell thyroid cancer was also resected during the parathyroid exploration and small meningioma was found on brain MRI. Her general condition has markedly improved and her adrenal mass and meningioma are being closely observed now. We could find the loss of heterozygosity of the MEN1 locus in parathyroid glands, suggesting a MEN1-related tumor, but not a germline mutation. Considering a variety of phenotypic expression and a limitation of current molecular analysis, periodic follow up will be needed in patients with a MEN1-like phenotype.
