Protective Effect of Sauchinone Against Regional Myocardial Ischemia/Reperfusion Injury: Inhibition of p38 MAPK and JNK Death Signaling Pathways.
10.3346/jkms.2012.27.5.572
- Author:
Seok Jai KIM
1
;
Cheol Won JEONG
;
Hong Beom BAE
;
Sang Hyun KWAK
;
Jong Keun SON
;
Chang Seob SEO
;
Hyun Jung LEE
;
JongUn LEE
;
Kyung Yeon YOO
Author Information
1. Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju, Korea. kyyoo@jnu.ac.kr
- Publication Type:Brief Communication ; Research Support, Non-U.S. Gov't
- Keywords:
Sauchinone;
Cardioprotection;
Ischemia/reperfusion Injury;
Cell Death Signaling Pathway;
Reperfusion Injury Salvage Kinase Pathway
- MeSH:
Animals;
Benzopyrans/*pharmacology;
Dioxoles/*pharmacology;
Glycogen Synthase Kinase 3/metabolism;
JNK Mitogen-Activated Protein Kinases/*metabolism;
Mitogen-Activated Protein Kinase 1/metabolism;
Mitogen-Activated Protein Kinase 3/metabolism;
Myocardial Reperfusion Injury/*metabolism/pathology/prevention & control;
Phosphorylation;
Protective Agents/*pharmacology;
Rats;
Signal Transduction/*drug effects;
p38 Mitogen-Activated Protein Kinases/*metabolism
- From:Journal of Korean Medical Science
2012;27(5):572-575
- CountryRepublic of Korea
- Language:English
-
Abstract:
Sauchinone has been known to have anti-inflammatory and antioxidant effects. We determined whether sauchinone is beneficial in regional myocardial ischemia/reperfusion (I/R) injury. Rats were subjected to 20 min occlusion of the left anterior descending coronary artery, followed by 2 hr reperfusion. Sauchinone (10 mg/kg) was administered intraperitoneally 30 min before the onset of ischemia. The infarct size was measured 2 hr after resuming the perfusion. The expression of cell death kinases (p38 and JNK) and reperfusion injury salvage kinases (phosphatidylinositol-3-OH kinases-Akt, extra-cellular signal-regulated kinases [ERK1/2])/glycogen synthase kinase (GSK)-3beta was determined 5 min after resuming the perfusion. Sauchinone significantly reduced the infarct size (29.0% +/- 5.3% in the sauchinone group vs 44.4% +/- 6.1% in the control, P < 0.05). Accordingly, the phosphorylation of JNK and p38 was significantly attenuated, while that of ERK1/2, Akt and GSK-3beta was not affected. It is suggested that sauchinone protects against regional myocardial I/R injury through inhibition of phosphorylation of p38 and JNK death signaling pathways.
