The Histopathologic Effects of SS-cream in Local and Systemic Organs after Applying the SS-cream on Glans Penis of Rabbit and Rat.
- Author:
Zhong Cheng XIN
1
;
Young Deuk CBOI
;
Do Hwan SEONG
;
Hyung Ki CHOI
;
Nam Hoon CHO
Author Information
1. Department of Urology, Yonsei University, College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
SS-cream;
Histopathology;
Rabbit;
Rat
- MeSH:
Animals;
Burns;
Estrogens, Conjugated (USP);
Kidney;
Liver;
Lymphocytes;
Male;
Penis*;
Premature Ejaculation;
Rats*
- From:Korean Journal of Urology
1995;36(12):1339-1344
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
SS-cream is a topical agent containing 9 oriental herbs for treating the premature ejaculation. In preclinical tria1, SS-cream has been effective in the treatment of premature ejaculation with only mild side effect of local penile burning sense, and other serious complications were not noted, but there were no exact histopathologic effects as for topical applying. Therefore. we investigated the local and systemic histopathologic effects of SS-cream after applying the SS-cream on glans penis with the rabbits(n=38) and white rats(n=10). SS-cream exhibited no histopathologic changes in the glans penis with temporary application. In long-term application(3-5 months) of the SS-cream on glans penis, there was a transient lymphocytes infiltration and mild congestion at submucous layer of the glans penis, which was subsided spontaneously in a 7 days later after the end of study. But these phenomena were not seen in group which the SS-cream was washed away 30 minutes later with applying on the glans penis. The other systemic histopathologic changes(testes, kidney, liver and spleen) were not seen in any experiments. With these results, we can conclude that there were no significant local and systemic histopathological changes in the temporary and long-term application of SS-cream on glans penis, and the SS-cream is proven safe for treating the premature ejaculation without untoward local and systemic histopathologic changes if it is respectively washed away 30 minutes later after the application on the glans penis.
