Effects of the Oral Administration of Mosapride Citrate on Capsule Endoscopy Completion Rate.
- Author:
Yosuke IDA
1
;
Naoki HOSOE
;
Hiroyuki IMAEDA
;
Rieko BESSHO
;
Riko ICHIKAWA
;
Makoto NAGANUMA
;
Takanori KANAI
;
Toshifumi HIBI
;
Haruhiko OGATA
Author Information
1. Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
- Publication Type:Original Article
- Keywords:
Capsule endoscopy;
Mosapride;
Prokinetics
- MeSH:
Administration, Oral;
Benzamides;
Body Mass Index;
Capsule Endoscopy;
Cecum;
Citric Acid;
Gastrointestinal Motility;
Hospitalization;
Morpholines;
Multivariate Analysis;
Polyethylene Glycols;
Retrospective Studies
- From:Gut and Liver
2012;6(3):339-343
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: In capsule endoscopy (CE), the capsule does not always reach the cecum within its battery life, which may reduce its diagnostic yield. We evaluated the effect of mosapride citrate, a 5-hydroxytryptamine-4 agonist that increases gastrointestinal motility, on CE completion. METHODS: In a retrospective study, we performed univariate and multivariate analyses for 232 CE procedures performed at our hospital. To identify factors that affect CE completion, the following data were systematically collected: gender, age, gastric transit time (GTT), nonsteroidal anti-inflammatory drug administration, previous abdominal surgery, hospitalization, use of a polyethylene glycol solution, use of mosapride citrate (10 mg), body mass index (BMI), and total recording time. RESULTS: The univariate analysis showed that oral mosapride citrate, GTT, and BMI were associated with improved CE completion. Multivariate analyses showed that oral mosapride citrate (odds ratio [OR], 1.99; 95% confidence interval [CI], 1.01 to 3.91) and GTT (OR, 2.34; 95% CI, 1.13 to 4.87) were significant factors for improving the CE completion. Oral mosapride citrate significantly shortened the GTT and small bowel transit time (SBTT). CONCLUSIONS: Oral mosapride citrate reduced the GTT and SBTT during CE and improved the CE completion rate.
