Effect of a Diet with Unrestricted Sodium on Ascites in Patients with Hepatic Cirrhosis.
- Author:
Xi Bing GU
1
;
Xiao Juan YANG
;
Hong Ying ZHU
;
Bo Yu XU
Author Information
1. Department of Liver Disease, Wuxi Hospital for Infectious Diseases, Wuxi, China. gxb188681@sina.com
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Liver cirrhosis;
Ascites;
Sodium-unrestricted diet;
Albumin;
Renal circulation
- MeSH:
Ascites;
China;
Diet;
Diet, Sodium-Restricted;
Diuresis;
Humans;
Liver;
Liver Cirrhosis;
Plasma;
Renal Circulation;
Renin;
Sodium
- From:Gut and Liver
2012;6(3):355-361
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: There has been debate on whether a sodium-restricted diet (SRD) should be used in cirrhotic patients with ascites in China in recent years. The purpose of this study was to compare the effect of sodium-restricted and unrestricted diets on plasma renin activity (PRA), renal blood flow (RBF) and ascites in patients with liver cirrhosis. METHODS: Two hundred cirrhotic patients with ascites were randomly divided into two groups (98 cases in the sodium-unrestricted diet [SUD] group and 102 cases in the SRD group); 95 patients (96.94%) in the SUD group and 97 patients (95.1%) in the SRD group had post-hepatitis B cirrhosis. RESULTS: Blood sodium and RBF were higher in SUD group than in SRD group (p<0.001), while PRA were significantly lower in SUD group than the SRD group 10 days after treatment (p<0.001). Renal impairment caused by low blood sodium was higher in SRD group than in SUD group (p<0.01). Ascites disappeared in higher proportion of patients in SUD group than in SRD group (p<0.001). CONCLUSIONS: SUD can increase the level of blood sodium and RBF, and be beneficial to diuresis and ascite reduction and disappearance.
