Effect of Nonalcoholic Fatty Liver Disease on the Development of Type 2 Diabetes in Nonobese, Nondiabetic Korean Men.
- Author:
Chang Wook CHON
1
;
Bum Soo KIM
;
Yong Kyun CHO
;
Ki Chul SUNG
;
Ji Cheol BAE
;
Tae Wan KIM
;
Hyun Sun WON
;
Kwan Joong JOO
Author Information
1. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. Choyk2004.cho@samsung.com
- Publication Type:Original Article
- Keywords:
Nonalcoholic fatty liver disease;
Type 2 diabetes mellitus;
Metabolic syndrome
- MeSH:
Blood Glucose;
Body Mass Index;
Diabetes Mellitus, Type 2;
Fasting;
Fatty Liver;
Follow-Up Studies;
Glucose;
Humans;
Male
- From:Gut and Liver
2012;6(3):368-373
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: We have a limited understanding of the effect of nonalcoholic fatty liver disease (NAFLD) on the development of type 2 diabetes. METHODS: The study subjects included male who had received biennial medical check-ups between 2005 and 2009 and who had been diagnosed with fatty liver disease. The subjects with sustained NAFLD (FL, n=107) and sustained non-NAFLD (NFL, n=1,054) were followed to determine the development of type 2 diabetes. RESULTS: In the FL group, there were more subjects with impaired fasting glucose (IFG), type 2 diabetes and high HOMA-IR than there were in the NFL group during the 5-year follow-up period (32.7 vs. 17.6%, 1.9 vs. 0.3%, 17.9 vs. 5.2% respectively, p<0.05). The FL group showed a higher risk than NFL group for abnormal glucose metabolism as determined using IFG (odds ratio [OR], 2.13; confidence interval [CI], 1.36 to 3.35), type 2 diabetes (OR, 7.63; 95% CI, 1.03 to 56.79) and high HOMA-IR (OR, 3.25; 95% CI, 1.79 to 5.91) and metabolic parameters such as body mass index (OR, 3.35; 95% CI, 1.87 to 6.02), triglyceride (OR, 3.05; 95% CI, 1.92 to 4.86) and fasting blood sugar (OR, 2.18; 95% CI, 1.39 to 3.41). CONCLUSIONS: Sustained NAFLD appears to be associated with an increased risk for the development of type 2 diabetes and deterioration of metabolic parameters in non-obese, non-diabetic Korean men.
