Serum Levels of Inhibin A and Inhibin B During Menstrual Cycle.
- Author:
Jang Heub KIM
1
;
Yoon Jin LEE
;
Seong Jin HWANG
;
Hyun Hee JO
;
Dong Jin KWON
;
Eun Jung KIM
;
Jin Hong KIM
;
Jin Woo LEE
Author Information
1. Department of Obstetrics and Gynecology, Catholic University Medical College, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Inhibin A;
Inhibin B;
Follicle;
Corpus luteum;
ELISA
- MeSH:
Corpus Luteum;
Enzyme-Linked Immunosorbent Assay;
Female;
Follicular Phase;
Humans;
Inhibins*;
Luteal Phase;
Menstrual Cycle*
- From:Korean Journal of Obstetrics and Gynecology
2003;46(6):1145-1150
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To understand the physiologic effects and secretion pattern of inhibin A and inhibin B throughout menstrual cycle in the normal reproductive women, serum values of inhibin A and inhibin B were measured. METHODS: Inhibin A and inhibin B levels were measured in 320 serum samples from 160 normal reproductive women by solid phase sandwich ELISA. RESULTS: In the normal reproductive women, inhibin A is secreted in low serum levels until the mid- proliferative phase, begins to increase in the late proliferative phase (16.53+/-1.57 pg/ml), reaches the peak in the early secretory and mid-secretory phase (45.56+/-2.37 and 45.85+/-2.08 pg/ml), and subsequently decreases in the late secretory phase. We found that inhibin B begins to increase in the early proliferative phase (65.40+/-4.08 pg/ml), is secreted in high concentration in the proliferative phase, reaches the peak in the ovulatory phase (110.74+/-9.83 pg/ml), and thereafter declines rapidly to the lowest level in the mid-secretory phase (29.59+/-2.08 pg/ml). CONCLUSION: In conclusion, serum inhibin A levels peak during the luteal phase, indicating the greatest production by the corpus luteum and serum inhibin B levels increase during the follicular phase, indicating the greatest production by follicles in early stage of development. Inhibin A is associated with the luteal function and inhibin B, the follicular function. Both inhibins are associated with the follicular maturation and development.
