High-Dose Zolpidem Dependence and Detoxification from Withdrawal Symptoms Using Diazepam.
10.4306/jknpa.2012.51.3.134
- Author:
Sang Jin RHEE
1
;
Seok Man KO
;
Jung Won CHOI
;
Hanson PARK
Author Information
1. Department of Psychiatry, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Addiction;
Dependence;
Detoxification;
Diazepam;
Withdrawal;
Zolpidem
- MeSH:
Benzodiazepines;
Diazepam;
Pyridines;
Receptors, GABA-A;
Seizures;
Sleep Initiation and Maintenance Disorders;
Substance Withdrawal Syndrome
- From:Journal of Korean Neuropsychiatric Association
2012;51(3):134-138
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Zolpidem is a nonbenzodiazepine hypnotic for the treatment of insomnia, and known as a relatively-safe medication. However, there have been several case reports of zolpidem abuse aand dependence these days. Even though some withdrawal symptoms like seizures can occur, there has not been any standard detoxification method until now. A high dose of zolpidem has similar pharmacological properties as the rest of the benzodiazepines, even though the usual dose of zolpidem has a selectivity to the type 1 benzodiazepine receptors. We report a rare case of high-dose addiction and successful detoxification by cross-titration with diazepam.
